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Synthesis and antimicrobial evaluation of N-(3- benzoxazol-2-yl-phenyl)-acrylamide
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| Author:
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MOHAMED ABDELGAWAD
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| Abstract:
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N-(3-benzoxazol-2-yl-phenyl)-acrylamide has been synthesized as an expected product by reacting 3-
benzoxazol-2-yl-phenylamine (1) with chloropropioanyl chloride. The 3-benzoxazol-2-yl-phenylamine (1) was
prepared according to reported methods through condensation reaction of 2-aminophenole with 3-aminobenzoic
acid in presence of polyphosphoric acid (PPA). The acrylamide derivative 3 was screened for antimicrobial activity.
The acrylamide 3 showed moderate inhibitory activity for both C. neoformans and leishmania species but the
acrylamide 3 has no antibacterial activity. The course of the reaction was found to be of high yield (87%) and the title
compound was spectroscopically confirmed and characterized by IR, 13C/1H-NMR, mass spectrometric techniques,
and elemental analysis.
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| Keyword:
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Benzoxazole; PPA; Acetamide; Acrylamide
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.04.070
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| Download:
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Request For Article
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