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The possible protective effect of Carthmustinctorius(leaves) on antituberculosis( Rifampin &Isoniazid)drugs –induced hepatotoxicity in rats.
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| Author:
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MAHDI THUWAINI, KARIM H. AL-DERAWI, HANAAS. KADHEM
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| Abstract:
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Anti-tuberculosis namely Rifampin (RIF) and Isoniazid (INH) yet represents a first-line drugs for the remedy and
protection of tuberculosis disease, but various reactions frequently promote in patients administered this drug.
However, Methanolic extract of leaves of Carthmustinctorius has hepatoprotective activity which was investigated
against hepatotoxicity produced by administering a combination of two anti-tubercular drugs isoniazid and
rifampicin.Thecurrent study was assessed the possible protective effect of Carthmustinctorius extract on antituberculosis
namely (INH&RIF)drugs.So,this study was aimed at examine the possibility protect effect and mechanism
of carthmustinctorius extract against (INH&RIF)drugs-induced hepatotoxicity in rats.The present study esteem the in
vivo role of methanolic extract of leaves of Carthmustinctorius in protecting the liver against injury via anti-tuberculosis
namely (INH&RIF)drugs in rats and further explores the underlying mechanisms. We postulate that Carthmustinctorius
extract might protect the liver injury from anti-tuberculosis (INH&RIF)drugs. Moreover, forty male albino rats were
haphazerdly divided into 4 groups: Control group, INH + RIF treated group, (Carthmustinctorius extract 250g/kg/daily
for 28 days+ combination of RIF+ INH) treated group, and last sole of treated Carthmustinctorius extract 250g/kg/daily
for 28 days. The INH + RIF were orally administered at dose levels of 50mg/ kg–b.wt., daily for 4 weeks. As well as
these tissue of liverinjuries were quickly separated and fixed in 10% formalin and exposed to histopathological
studies. Statistical analysis was carried out using t-test and analysis of variance (ANOVA).Administration of Antituberculosis
drugs namely (RIF& INH) to rats induced marked hepatotoxicity as evidenced by significant rise in
serum levels of ALT, AST, ALP and total bilirubin at (p< 0.05). The current study shows that the effectof methanolic
extract of leaves of Carthmustinctoriuson some blood serum criteria of liver functions of anti- tuberculosis drugs. The
study showed that relative lung weight to animals body weight was significantly increased at (P?0.05) in (RIF& INH)
treated animals in comparison to the other groups. The results of present study powerfully indicated that methanolic
extract of leaves of Carthmustinctorius has hepatoprotective action against RIF&INH-induced hepatic injury in rats.
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| Keyword:
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Carthmustinctorius, antituberculosis drugs, (RIF& INH), histopathological, body weight, biochemical parameters, hepatotoxicity.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.04.083
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| Download:
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