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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Preparation of nanohybrid hypolipidemic from simvastatin drugand study its effect on the lipid profile in white male rats induced hyperlipidemia

Author: DR.ASEEL SABOUR, ZAINAB ZAIDAN MATSHAR
Abstract: This study was designed to determine the effect of the nanohybridhypolipidemic ofsimvastatin drug on lipid profile of white male rats induced hyperlipidemia . The nanohybrid of the drug was initially prepared and diagnosed as the drug was loaded onto zinc oxide layers. The results of the test showed the infrared spectrum FT-IR obtained many of the distinctive movements of the bonds and group. XRD also showed a new diffraction in the spectrum of the nanohybrid drug compared to the zinc oxide carrier spectrum, indicating that the drug under study was a nanohybrid drug. The results of the examination of the atomic force microscope revealed that the average diameter of the nanoparticles of the hybrid drug Sim-Zno was 92.28 nm.To test the effectiveness of this compound compared to free simvastatin, the current study included two experiments, the first experiment used 50 males of adult white rats divided into two groups, the first group control fed normal diet and distilled water, the second group was induced hyperlipidemia by feeding on (cholesterol 2%, bile acid salt 3% and lard fat 8%) for two months. It was ascertained of hyperlipidemia by measuring lipid profile, the results showed increased high blood fat levels compared with control group. The second experiment divided the remaining animals from the second group in addition to the control group to five groups, control group considered as negative control, T1 group as positive control, T2, T3 and T4 groups were administered with the free 40 mg/kg simvastatin drug,nanohybrid of the drug at a dose40mg/kg and Zinc oxide at a dose of 30 mg/kg respectively and concurrently fed with high-fat diet for 30 days. The results showed a significant increase in the levels of (VLDL, LDL, TG, TC) and a significant decrease in (HDL) level in positive control compared to negative control, while the cause of the drug free Simvastatin improved lipid levels also showed the role of the nanohybridof the simvastatin in the improvement lipid profile by increasing the bioavailability of drug and increasing its absorption. The T4 group showed no significant differences (P> 0.05) in TC, TG, LDL, HDL and VLDL levels.
Keyword: Simvastatin, nanoparticles, lipid profile, rats
DOI: https://doi.org/10.31838/ijpr/2018.10.04.085
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