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Preparation of nanohybrid hypolipidemic from simvastatin drugand study its effect on the lipid profile in white male rats induced hyperlipidemia
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| Author:
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DR.ASEEL SABOUR, ZAINAB ZAIDAN MATSHAR
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| Abstract:
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This study was designed to determine the effect of the nanohybridhypolipidemic ofsimvastatin drug on lipid profile of
white male rats induced hyperlipidemia . The nanohybrid of the drug was initially prepared and diagnosed as the drug
was loaded onto zinc oxide layers. The results of the test showed the infrared spectrum FT-IR obtained many of the
distinctive movements of the bonds and group. XRD also showed a new diffraction in the spectrum of the nanohybrid
drug compared to the zinc oxide carrier spectrum, indicating that the drug under study was a nanohybrid drug. The
results of the examination of the atomic force microscope revealed that the average diameter of the nanoparticles of
the hybrid drug Sim-Zno was 92.28 nm.To test the effectiveness of this compound compared to free simvastatin, the
current study included two experiments, the first experiment used 50 males of adult white rats divided into two
groups, the first group control fed normal diet and distilled water, the second group was induced hyperlipidemia by
feeding on (cholesterol 2%, bile acid salt 3% and lard fat 8%) for two months. It was ascertained of hyperlipidemia by
measuring lipid profile, the results showed increased high blood fat levels compared with control group. The second
experiment divided the remaining animals from the second group in addition to the control group to five groups,
control group considered as negative control, T1 group as positive control, T2, T3 and T4 groups were administered
with the free 40 mg/kg simvastatin drug,nanohybrid of the drug at a dose40mg/kg and Zinc oxide at a dose of 30
mg/kg respectively and concurrently fed with high-fat diet for 30 days. The results showed a significant increase in the
levels of (VLDL, LDL, TG, TC) and a significant decrease in (HDL) level in positive control compared to negative
control, while the cause of the drug free Simvastatin improved lipid levels also showed the role of the nanohybridof
the simvastatin in the improvement lipid profile by increasing the bioavailability of drug and increasing its absorption.
The T4 group showed no significant differences (P> 0.05) in TC, TG, LDL, HDL and VLDL levels.
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| Keyword:
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Simvastatin, nanoparticles, lipid profile, rats
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.04.085
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| Download:
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