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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Carbamazepine Drug on Liver Ultrastructure in Female White Mice (Mus musculus)

Author: NAWAR JABER, NAHLA A. AL-BAKRI
Abstract: Epilepsy is the most common neurological disorder after Alzheimer and other cerebrovascular diseases. Antiepileptic drugs (AED`s) are one of the most important methods to prevent epileptic seizers. Antiepileptic drugs can cause damage to the liver which is the largest and most important glandular organ in the body with many other drugs. Carbamazepine (CBZ) is a known anticonvulsant that is widely used and known for a decade, it was used to treat trigeminal neuralgia, bipolar disorder and epilepsy and it can cause hepatotoxicity.In this study female white mice received CBZ suspension at a dose of 20 mg/kg/mouse via gastric gavage for 30 days, tissue samples were collected for scanning electron microscopy.Weobserved the adverse effects of the chronic use of CBZ that cause changes in the ultrastructure features of the liver to meet functional demands, loss of liver architecture, hepatocytes distortion , sinusoidal dilation, retraction and swollen of the sinusoidal endothelium, disappearance of some fenestrations in the endothelium and dilation of others, Kupffer cell enlargement and filopodia were noticed as an indication of activation due to chronic toxicity, distortion of the central and portal veins andcongestion
Keyword: Carbamazepine, Liver, Scanning electron microscope.
DOI: https://doi.org/10.31838/ijpr/2018.10.04.086
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