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Effect of Carbamazepine Drug on Liver Ultrastructure in Female White Mice (Mus musculus)
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| Author:
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NAWAR JABER, NAHLA A. AL-BAKRI
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| Abstract:
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Epilepsy is the most common neurological disorder after Alzheimer and other cerebrovascular diseases. Antiepileptic
drugs (AED`s) are one of the most important methods to prevent epileptic seizers. Antiepileptic drugs can cause
damage to the liver which is the largest and most important glandular organ in the body with many other drugs.
Carbamazepine (CBZ) is a known anticonvulsant that is widely used and known for a decade, it was used to treat
trigeminal neuralgia, bipolar disorder and epilepsy and it can cause hepatotoxicity.In this study female white mice
received CBZ suspension at a dose of 20 mg/kg/mouse via gastric gavage for 30 days, tissue samples were collected
for scanning electron microscopy.Weobserved the adverse effects of the chronic use of CBZ that cause changes in
the ultrastructure features of the liver to meet functional demands, loss of liver architecture, hepatocytes distortion ,
sinusoidal dilation, retraction and swollen of the sinusoidal endothelium, disappearance of some fenestrations in the
endothelium and dilation of others, Kupffer cell enlargement and filopodia were noticed as an indication of activation
due to chronic toxicity, distortion of the central and portal veins andcongestion
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| Keyword:
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Carbamazepine, Liver, Scanning electron microscope.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.04.086
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| Download:
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