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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparative Study of Duration of Spinal Anesthesia with Marcaine and Lidocaine plus Fentanyl between opium abuse and Non-nonuse patients

Author: SEYEDEH TABATABAEI, LEILA MALEKMAKAN, NARGES IZADPANAHI, AFSHIN MANSOURIAN
Abstract: Background: Spinal anesthesia length? is related to the type of anesthetic agent, dosage and additive materials such as epinephrine, ephedrine and opioids. In this study, we compared the duration of spinal anesthesia with Marcaine and Lidocaine plus Fentanyl in addicts and non-addicts patients undergoing Orthopedic Surgery Methods: This single blinded randomized clinical trial was performed on 200 males (height ranged 150-180 cm) who referred to the Shaheed Beheshti Hospital of Yasuj University of Medical Science due to the lower limb fracture. All patients have, American association standard class 1, and they were candidates for spinal anesthesia. The addicts or non-addicts groups were each divided into two subgroups. 3CC of Marcaine 5% was used for one subgroup, and the other subgroup injected 75 mg of 5% lidocaine plus 50 µgr of Fentanyl. The level of initial spinal anesthesia was elevated to T10. Duration of returning to the 4 levels of primary sensory levels was measured.. Results: A significant increase in the Spinal anesthesia length in both addict and non-addict patients who received Marcaine compared to the subgroups received lidocaine plus Fentanyl (P < 0.01). In addict subgroup received lidocaine plus fentanyl, Significant decrease during the return time of the sensory level (P < 0.01).Duration of decrease in sensory level in addict subgroups received Marcaine and Lidocaine plus Fentanyl was lower compared to non-addict patients (P < 0.0001). Conclusions: The final result of this study of this study, regardless of the anesthetic agent being used, duration of spinal anesthesia was shorter in addict patients compared to non-addict ones. Add of Fentanyl to lidocaine 5% increased the duration of spinal anesthesia in addict and non-addict patients. Marcaine can cause longer spinal anesthesia in both groups compared to lidocaine and fentanyl..
Keyword: Spinal anesthesia, Addict, Lidocaine, Fentanyl, Marcaine.
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