IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016).    Offical Sponser for International Conference in malaysia ,  https://www.icmhas.com/

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
PIPPHARMACON & IJPR 2018

PIPPHARMACON & IJPR 2018

Click to download
 

Article Detail

Label
Label
METHOD DEVELOPMENT AND VALIDATION FOR THE STABILITY INDICATING SIMULTANEOUS ESTIMATION OF TEZACAFTOR AND IVACAFTOR IN BULK AND ITS DOSAGE FORMS.

Author: R.KIRANJYOTHI* , M.BALAKRISHNAN, K.B.CHANDRASEKHAR
Abstract: A Stability-indicating reverse phase-high performance liquid chromatographic (RP-HPLC) method was developed and validated for the determination of Tezacaftor and Ivacaftor in its Pure form and its tablet dosage form using C18 column phenomenix (250mm*4.6mm,5µm) with a mobilephase consisting of Acetonitrilel:0.25Mm Potassium dihydrogen orthoPhosphate buffer pH 4.5(55:45v/v).The mobilephase was sonicated for 10 minutes and filtered through a 0.45 µm membrane filter at a flow rate of 1.5ml/min. The detection was carried out at 292nm and retention time of Tezacaftor and Ivacaftor was found to be 3.836min and 2.889 min. Method validation was Performed and Linearity was observed from 50-150%.Tezacaftor and Ivacaftor was subjected to stress conditions including acidic, alkaline, oxidative, photolysis,and thermal degradation and results showed that Tezacaftor was more sensitive towards Basic degradation and Ivacaftor was more sensitive towards oxidative degradation studies.
Keyword: Tezacaftor, Ivacaftor,RP-HPLC, Forced degradation ,Method validation
DOI: https://doi.org/10.31838/ijpr/2018.10.04.043
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
AICTE INTERNATIONAL CONFERENCE

AICTE Sponsored International Conference on Challenges, Opportunities and Newer Directions of Pharmacovigilance and Clinical Research in India

Download Brochure


For More Detail Visit www.pippharmacon.org
News & Events
hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus
Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477