IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016).    Offical Sponser for International Conference in malaysia ,  https://www.icmhas.com/

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
PIPPHARMACON & IJPR 2018

PIPPHARMACON & IJPR 2018

Click to download
 

Article Detail

Label
Label
The Effect of Hyponatremia on Short Term Prognosis in Patients with acute ST-Elevation Myocardial Infarction

Author: LAITH ALDABBAGH, SADIQ ALMUHANA, AMEER ZAINY, AHMED ALMUDAFFER, NAJAH HADI, MOHAMMED NOORI ALDUJAILY, GHASSAN AIED KAREEM
Abstract: The activation of the baroreceptor in acute STEMI, leads to activation of the sympathetic nervous system. this leads to release of hormones like vasopressin (AVP) and also activation of rennin-angiotensin system. This neurohormonal change is related to the severity of the myocardial damage. hyponatremia reflects these hormonal changes. So; serum sodium level may be an indicator of the severity of ST elevation MI (STEMI). The aim of this study is to evaluate in hospital prognosis of acute ST elevation myocardial infarction with hyponatremia. This prospective observational study was included 116 patients presenting with acute ST-elevation myocardial infarction admitted to coronary care unit (CCU) , in AL-Sader Medical City , Najaf , Iraq , during the period from ( April 2016 and February 2017 ) .Plasma sodium concentrations were taken on admission and at 24, 48 and 72 hours thereafter. The study subjects divided into three groups, group I,include 33 patients with hyponatraemia on admission, group II include 31 patients with hyponatraemia within 72 hours from admission, and control group include 52 patients with normal plasma sodium level (135-145 mmol/L).Study group is collectively of group I and group II (hyponatraemicpatients on admission and hyponatraemic patients within 72 hours), then compared with group III (control group " normonatremicpatient).In this study of 116 patients who presented with acute ST-elevation myocardial infarction (STEMI), hyponatremia was diagnosed in 33 patients (28.4%) at the time of admission , 31 patients (26.7%) within 72hours of admission (early developed hyponatremia) and 52 patients (44.9%) with normal serum sodium levelthe heart failure rate was statistically significant in the patients with hyponatremia (study groups ) than in patient with normonatremia (control group ) p -value < 0.001 , and statistically significant in sever hyponatremia p -value < 0.001 . The mortality rate was significantly higher in the patients with hyponatremia (study groups) than in patient with normonatremia (control group) p -value<0.001, and significantly higher in sever hyponatremia p –value <0.001. Hyponatremia in patients with acute ST-elevation myocardial infarction, is strongly associated with sever LV dysfunction and more mortality rate.
Keyword: STEMI , Hyponatremia, heart failure, MI.
DOI: https://doi.org/10.31838/ijpr/2018.10.04.022
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
AICTE INTERNATIONAL CONFERENCE

AICTE Sponsored International Conference on Challenges, Opportunities and Newer Directions of Pharmacovigilance and Clinical Research in India

Download Brochure


For More Detail Visit www.pippharmacon.org
News & Events
hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus
Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477