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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Analgesic and Antipyretic Activities of Ficus Bengalensis Bark

Author: UPLOADED BY-ADMIN, VIKAS V. PATIL, BHANGALE SC, NARKHEDE SB, JAWLE NM, PATIL VR
Abstract: The purpose of this investigation was to study the analgesic, antipyretic properties of the various (pet ether, chloroform, ethanol and water) extracts from bark of Ficus bengalensis (Moraceae) in rats. Dose of the various extracts 200mg/kg, i.p.were significantly reduced (p<0.001). The analgesic activity of bark of Ficus bengalensis was studied using hot-plate method and tail-immersion method in rats. The antipyretic activity of bark of Ficus bengalensis was studied in Brewer’s yeast-induced pyrexia in rats. The extract at all the doses used and the Aspirin significantly inhibited both the analgesic activity for hot plate and tail immersion method also in the antipyretic activity for the method of Brewer’s yeast-induced pyrexia in rats inflammation in a manner that was not dose dependent. The preliminary Phytochemical screening of the various extracts showed the presence of flavonoids, alkaloids, triterpenoids, tannins, saponins and steroids. The ethanolic extract were similar to aspirin (p<0.001) while the pet ether, chloroform, and water was weaker than the aspirin in analgesic as well as antipyretic activity of the bark of Ficus bengalensis. The higher analgesic effects of various extracts tested might back to the presence of flavonoids and phenolic compounds. The various extracts produced a significant inhibition of temperature elevation. These data suggest that the different extracts of the bark of Ficus bengalensis produce analgesic and antipyretic activities that could be due to the effects of one or a combination of the bio active components in each extract. The present study demonstrates the potential antipyretic and analgesic effect of Ficus bengalensis further supporting the claims by traditional medicine practitioners.
Keyword: Ficus bengalensis, analgesic, antipyretic, aspirin.
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