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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Teratogenicity Induced by a commercially available Insecticide Colonel-S® in the developing chick embryo

Author: NITU BHASKAR, LATA
Abstract: The aim of present work was to study the teratogenic potential of a commercial formulation of insecticide dicofol (Colonel-S) in the developing chick embryo. Fertilized eggs were immersed in aqueous emulsions of Colonel- S at the concentrations of 250, 500 and 1000 mg L-1 for 60 min at 37°C prior to incubation and kept for incubation till embryonic day (ED) 4, 7 and 16. It was found that administration of Colonel-S at 250 and 500 mg L-1 of dose levels resulted in significant decrease of survivability success of 16 day old chick embryo, while marked decrease in their body weight was observed on ED 4 at 500 mg L-1 dose concentration. A non significant increase in percentage of abnormal survivors exhibiting a spectrum of morphological malformations on ED 4, 7 and 16 and skeletal malformations only on ED 16 was observed. Among biochemical changes, embryonic total protein content was decreased significantly on ED 7 at 1000 mg L-1 of Colonel-S, whereas total glycogen content was depleted at its 1000 mg L-1 of dose on ED 4 and 500 mg L-1 of dose on ED 7. Among enzymes, the significant alteration was observed only in activity of alkaline phosphatase which showed significant elevation at 1000 mg L-1 and 500 mg L-1 of Colonel-S, respectively on ED 4 and 7 when compared with corresponding controls. From present result, Colonel-S can be considered as teratogenic agent, at the dose levels used at our laboratory conditions.
Keyword: Insecticide; dicofol; organochlorine; teratogenecity; chick embryo
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