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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

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DEVELOPMENT OF COMPOSITION AND MANUFACTURINGMETHOD FOR COMBINATION DRUG PRODUCT BASED ONCHITOSAN-CONTAINING PHARMACEUTICAL SUBSTANCES

Author: LILIANA BRKICH*, NATALIA VALERYEVNA PYATIGORSKAYA, GALINA EDUARDOVNA BRKICH, IVAN IVANOVICH KRASNYUK, LYUDMILA ANATOLIEVNA KOROL
Abstract: The composition described in current article is based on derivatives of glucosamine and acrylate polymers and is intended for treatment of various infected wounds. A semi-transparent gel demonstrates complex therapeutic activity due to several active pharmaceutical ingredients (AFIs): chitosan, chymopsin, miramistin, and lidocaine hydrochloride. Mechanism of action of the developed drug is complex and includes several therapeutic effects: enzymatic biochemical wound debridement due to lysis of denaturated proteins (without healthy tissues damaging); indirect antimicrobial activity due to chymopsin that promotes lysis of microbial growth medium; direct antimicrobial effect is provided by miramistine; and the pain is reduced by lydocaine and intrinsic cooling effect of gel dosage form. Generalizing the literature data about the products used in the infected wounds treatment, the following AFIs were chosen for the development of the topical gel: complex of proteolytic agent chymopsin and chitosan, chitosan-miramistin complex, and lidocaine anesthetic. Hydroxypropyl methylcellulose, polyacrylamide, and glycerol were utilized as excipients. Proper development of vehicles for gels used in wound treatment can be justified by the necessity of soft action on the wound, required cooling effect, good release of AFIs from the matrix, and prevention of microbial growth.
Keyword: miramistin complex (CMC), chitosan – chymopsin complex (CCC),infected wounds, wound treatments,lysozyme, chlorhexidine, miramistin,hydroxypropyl methylcellulose, polyacrylamide.
DOI: https://doi.org/10.31838/ijpr/2018.10.04.025
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477