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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

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Impact Factor: 1.46

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Effects of Long Term Administration of Echinacea in Addition with Vaccination on General Condition and Liver and Renal Performance in Dogs

Author: YASAMAN BIAZAR*, REZA AVIZEH, MASOUD GHORBANPOUR, HOSSEIN NAJAFZADEH VARZI, MOHAMMAD RAZIJALALI
Abstract: Echinacea is one of the more recognized herbs associated with immune modulation in human and animals. Until now little work has been done to evaluate its effects in dogs. The aim of this study was to evaluate the effects of long-term administration of Echinacea on some biochemical and hematological parameters in dogs. For this purpose, 15 adult healthy dogs of mixed breed were divided into three equal groups. Dogs in group 1 received orally extract of Echinacea purpura for a period of 28 days and canine polyvalent vaccine on the seventh day.Dogs in groups 2 and 3 received Echinacea purpura and canine polyvalent vaccine, respectively, at values similar to those of group 1.On days 0, 28 and 56 days after Echinacea feeding, blood samples were collected from all dogs and serum hematologic and biochemical parameters including alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, albumin and total protein were measured.Echinacea increased significantly the number of red and white blood cells as well as lymphocytes and hemoglobin and also significantly decreased the number of neutrophils (p<0.05). Vaccination alone resulted in a significant increase in white blood cell count (p<0.05). This study proved that long-term feeding of Echinacea in dogs while increased blood parameters, especially the red blood cells, had no complications and toxicity on hematologic and biochemical parameters.
Keyword: Echinacea, Vaccination, Hematology, Biochemistry, Dog
DOI: https://doi.org/10.31838/ijpr/2018.10.04.054
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477