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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Experimental evaluation of Saindhavadya Ghruta with special reference to its anti-convulsant activity

Author: DR. S.N., KRISHNAMURTHY M S, RAVISHANKAR.B.
Abstract: Convulsion is a condition which causes lot of agony to the patients. Even though there are many modern medicines to treat convulsions, they have failed to manage the condition effectively. They even cause side- effects on long term consumption. Hence, there is a need for the rational development of more safer and effective Ayurvedic medicines to treat convulsions which are even devoid of side-effects. Such a need prompted this study, which encompasses the information of evaluation of anti-convulsant activity of Saindhavadya Ghruta. Anti-convulsant activity was assessed in 3 animal models - PTZ induced chemo convulsion in mice, MES induced electro convulsion in rats and PTZ induced kindling in mice. The observations were recorded under various parameters and statistically analysed. Saindhavadya Ghruta showed moderate and mild anti-convulsant activity in PTZ induced convulsion in mice and MES induced convulsion in rats respectively. In PTZ induced kindling in mice, Saindhavadya Ghruta showed statistically high anti-convulsant activity. Findings revealed that Saindhavadya Ghruta can be effectively used to decrease the frequency and severity of seizures and also increase the tolerance to seizure activity. Even the long term administration of the test drug in the kindling did not produce CNS depression or sedation effect suggesting it was devoid of major side effects of modern anti-convulsants.
Keyword: Saindhavadya Ghruta, Anti - convulsant, PTZ, MES, Kindling.
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