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Development and evaluation of polyherbal ointments for anti-inflammatory therapy
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| Author:
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JITENDRA YADAV, DR. BIREN N. SHAH
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| Abstract:
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In the present investigation, the aqueous and methanolic extracts are screened for its anti-inflammatory activity and the effective dose is used to formulate ointment using different ointment bases. The methanolic and aqueous extracts of Lagenaria siceraria reduced the carrageenan induced rat paw edema by 37.50 % and 62.50 % respectively on oral administration of 200 mg / kg body wt. The methanolic and aqueous extracts of Ocimum gratissimum reduced the carrageenan induced rat paw edema by 61.25 % and 36.25 % respectively on oral administration of 100 mg / kg body wt., while the methanolic and aqueous extracts of Moringa oleifera reduced the edema induced by carrageenan by 60.00 % and 33.75 % respectively on oral administration of 600 mg / kg body wt., as compared to the untreated control group. Diclofenac sodium at 100 mg / kg body wt. inhibited the edema volume by 75.00 %. All the formulation were screened for its anti-inflammatory potential. TSF-3 showed most-significant activity by reducing 66.67 % edema at 4th hour, while TSF-1, TSF-2 and TSF-4 showed 55.56 %, 59.26 % and 37.04 % reduction in paw edema respectively, as compared to the untreated control group. The standard drug inhibited the edema volume by 74.07 % (p<0.05).
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| Keyword:
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Moringa oleifera, Ocimum gratissimum, Lagenaria siceraria, Anti-inflammatory activity, carrageenan, edema
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| EOI:
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| DOI:
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