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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF ACYCLOVIR AND HYDROCORTISONE IN BULK

Author: JINKAL SONI, DR. VANDANA B. PATEL
Abstract: A simple, precise and accurate UV Spectrophotometric methods namely Dual Wavelength method and First order derivative method have been developed for simultaneous estimation of acyclovir and hydrocortisone. In Dual wavelength method, difference in absorbance was measured at 229.6 nm and 253.2 nm for acyclovir (iso-absorptive wavelength for hydrocortisone) and at 243.0 nm and 264.8 nm for hydrocortisone (iso-absorptive wavelength for acyclovir) in methanol. In First order derivative method, absorbance was measured at 242.0 nm for acyclovir (Zero Crossing Point of hydrocortisone) and at 220.4 nm for hydrocortisone (Zero Crossing Point of acyclovir) in methanol. For both the developed methods linearity was observed in the concentration range of 2-14 µg/ml for both the drugs. Results of validation clearly revealed that both the methods are accurate and precise and showed potential utility for simultaneous estimation of both the drugs in its combination.
Keyword: Acyclovir (ACV), Hydrocortisone (HCS), Dual wavelength method, First order derivative method
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