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Pharmacological Evaluation of Clerodendrum Philippinum Schauer Flowers for Antianxiety and Central Nervous System Depressant Activity
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UPLOADED BY-ADMIN, K.G.LALITHA1, R SATHISH, R.GAYATHRI, S.KARTHIKEYAN, P.KALAISELVI, G. MUTHUBOOPATHI, T.VENKATACHALAM
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| Abstract:
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The research work deals with the ethanolic extract of Clerodendrum philippinum schauer flowers for anti
anxiety and central nervous system depressant activity. The C.philippinum flowers are known to contain sterols,
flavonoid, glycosides and phenyl propanoid derivatives as chemical components and are reported to have antifungal
activity. It is used as folk medicine in the treatment of colic pain. In the present study the elevated plusmaze
test models were used to evaluate anti-anxiety activity and locomotor activity was evaluated on actophotometer
with 125 and 250 mg/kg p.o. doses of C.philippinum. The ethanolic extract of the C.philippinum flowers
(125 and 250 mg/kg p.o) significantly (P > 0.01) decreased loco motor activity (45.20%, 53.47 %) and significantly
(P > 0.01) increased the number of entries, time spent and rears in open arm of the elevated plus maze
model.
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| Keyword:
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Clerodendrum philippinum, locomotor activity, plus maze
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