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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Pharmacological Evaluation of Clerodendrum Philippinum Schauer Flowers for Antianxiety and Central Nervous System Depressant Activity

Author: UPLOADED BY-ADMIN, K.G.LALITHA1, R SATHISH, R.GAYATHRI, S.KARTHIKEYAN, P.KALAISELVI, G. MUTHUBOOPATHI, T.VENKATACHALAM
Abstract: The research work deals with the ethanolic extract of Clerodendrum philippinum schauer flowers for anti anxiety and central nervous system depressant activity. The C.philippinum flowers are known to contain sterols, flavonoid, glycosides and phenyl propanoid derivatives as chemical components and are reported to have antifungal activity. It is used as folk medicine in the treatment of colic pain. In the present study the elevated plusmaze test models were used to evaluate anti-anxiety activity and locomotor activity was evaluated on actophotometer with 125 and 250 mg/kg p.o. doses of C.philippinum. The ethanolic extract of the C.philippinum flowers (125 and 250 mg/kg p.o) significantly (P > 0.01) decreased loco motor activity (45.20%, 53.47 %) and significantly (P > 0.01) increased the number of entries, time spent and rears in open arm of the elevated plus maze model.
Keyword: Clerodendrum philippinum, locomotor activity, plus maze
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