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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Natural and Artificial Superdisintegrants in the Formulation of Fast Dissolving Diclofenac

Author: UPLOADED BY-ADMIN, YADAV NIKKU, FEGADE HARSHAL
Abstract: Patient compliance is gaining significant importance in design of various type of dosage form. Fast Dissolving Tablet instead of dissolving or disintegrating in water is expected to dissolve or disintegrate in oral cavity without drinking water. In the present study, the effects of a natural superdisintegrant Plantago ovata and synthetic superdisintegrants like sodium starch glycolate (SSG), Crosspovidone and Croscarmellose sodium (Ac-di-sol) were compared in the formulations of fast dissolving tablets (FDT). FDTs of Diclofenac (model drug) were prepared by direct compression method. These tablets were evaluated for weight variation, hardness, thickness, disintegration time, wetting time, water absorption ratio, In vitro disper-sion, In vivo disintegration time, friability and dissolution. Swelling index was also investigated with an aim to compare the swelling property of Plantago ovata with Sodium starch glycolate (SSG), Crosspovidone (CP) and Ac-di-sol. Among all the super disintegrants, Plantago ovata showed the highest swelling index. Diclofenac is a non-steroidal anti-inflammatory drug and used for in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondilitis. Hence, the present study revealed that this natural superdisintegrants showed better disintegrating property than the most widely used synthetic super disintegrants like SSG, Crosspovidone and Ac-di-sol in the formulations of FDTs.
Keyword: Superdisintegrants, Diclofenac, Plantago ovata, Fast dissolving tablet.
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