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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL, DICLOFENAC POTASSIUM AND FAMOTIDINE IN ITS COMBINED PHARMACEUTICAL DOSAGE FORM

Author: ZEENAT SAMLAYAWALA, SHAILESH K KORADIA
Abstract: A simple, precise and accurate isocratic RP-HPLC method have been developed for the simultaneous estimation of PCM, DCP and FAMO in their combined pharmaceutical dosage form. Chromatographic separation was achieved on a ODS Hypersil C18 (250 x 4.6 mm i.d., 5µm) column, kept at ambient temperature, using a mobile phase consisting of 20 mM phosphate buffer (pH 3.5) : methanol (80:20 v/v) at a flow rate of 1.0 mL/min and UV detection at 217 nm. The linearity was observed in the concentration range of 10-60 µg/mL, 2.5-15 µg/mL and 1-10 µg/mL for Paracetamol, Diclofenac potassium and Famotidine respectively. The % recovery was found to be 99.81-101.25%, 99.63-100.85% and 99.63-100.66% for Paracetamol, Diclofenac potassium and Famotidine respectively. The developed method can be successfully applied in routine quality control analysis.
Keyword: Paracetamol, Diclofenac potassium, Famotidine, RP-HPLC method, simultaneous estimation
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0.12
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