|
Synthesis of novel (2,4-dimethoxy-3-((5-phenyl- 1,3,4-oxadiazol-2- yl)methoxy)phenyl)(phenyl)methanones and their antibacterial activity.
|
|
| Author:
|
SHASHIKANTH S, V. SRINIVASA MURTHY
|
| Abstract:
|
In the current study, a series of novel (2,4-dimethoxy-3-((5-phenyl-1,3,4-oxadiazol-2-
yl)methoxy)phenyl)(phenyl)methanones (9a-o), were synthesized by reacting 2-(chloromethyl)- 5-phenyl-1,3,4-
oxadiazole (8a-d) with aryl (3-hydroxy-2, 4-dimethoxyphenyl) methanones (4a-e) using potassium carbonate. The
chemical structure of the newly synthesized compounds was characterized by analytical and spectral (1HNMR,
13CNMR and HRMS) techniques. The desired title compounds were screened for qualitative (zone of inhibition)
by agar well method respectively. Among the synthesized compounds in the series, the compounds 9b, 9c, 9f and
9l were found to show major antibacterial activity at lower concentration, against Gram positive bacteria such
as Bacillus subtilis, staphylococcus aureus and Gram negative bacteria such as Salmonella typhimurium
Escherichia coli, Pseudomonas aeruginosa and Klebsiellapneumoniae. The rest of the compounds exhibited
adequate antibacterial activity when compared to the standard positive controls Chloramphenicol.
|
| Keyword:
|
2,6-dimethoxy phenol, aryl (3-hydroxy-2, 4-dimethoxyphenyl) methanones, (2,4- dimethoxy-3-((5- phenyl-1,3,4-oxadiazol-2-yl)methoxy)phenyl)(phenyl)methanone, antibacterial activity.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2018.10.03.076
|
| Download:
|
Request For Article
|
|
|