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OXIDATION OF QUETIAPINE BY POTASSIUM DICHROMATE IN ACID MEDIUM: A KINETIC STUDY
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| Author:
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SAYYED HUSSAIN*, SYED YOUSUFHUSSAIN, GULAM FAROOQ MUSTAFA, SAYYED SALIM
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| Abstract:
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Kinetics of oxidation of quetiapine using potassium dichromate as oxidizing agent in acid medium was studied
spectrophotometrically at 520 nm. The result interprets that rate of oxidation is first order with respect to potassium
dichromate and quetiapine where as it does not depend on the concentration of acid. The stoichiometry of the
reaction was found that one mole of oxidant is consumed for oxidation of three moles of quetiapine and the product
found is quetiapine N-oxide. From the results of kinetic studies, reaction stoichiometry and product analysis with
suitable mechanism of the reaction was proposed. Based on results of the reaction at different temperatures, the
activation parameters with respect to the slow step of the proposed mechanism was calculated.
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| Keyword:
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Kinetics, Oxidation, Quetiapine, Potassium Dichromate
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.03.075
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| Download:
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