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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Preclinical Screening Models for Sexual Behavior in Female Rodents: A Review

Author: UPLOADED BY-ADMIN, NEERAJ S. VYAWAHARE, VIRENDRA G. KAGATHARA, AVINASH A HADAMBAR, R. RAJENDRAN, BHARGAV H. MEHTA
Abstract: Studies of sexual behavior are particularly suitable for analyses of behavioral and neurobiological mechanisms of motivation. Epidemiological studies have shown that sexual desire disorders are common, particularly in women. Psychological treatments for such disorders are time consuming, and the outcome is uncertain. Therefore, it is very likely that many individual would prefer a reliable pharmacological treatment without side effects. The systemic development of such treatment requires undoubtedly a good preclinical model. On the other hand, the valid and reliable model of rodent sexuality would be of great utility to study the behavioral and neurobiological basis of sexual motivation, due to similarities in basic neural and behavioral mechanisms controlling sexual desire in humans and rodents. In light of this, the present review focuses on the various preclinical screening models and methodologies used to evaluate and screen the compounds likely to affect the various aspects of sexual behavior in female rodents.
Keyword: Behavioral, Epidemiological, neurobiological, preclinical model
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0.12
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