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Preclinical Screening Models for Sexual Behavior in Female Rodents: A Review
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UPLOADED BY-ADMIN, NEERAJ S. VYAWAHARE, VIRENDRA G. KAGATHARA, AVINASH A HADAMBAR, R. RAJENDRAN, BHARGAV H. MEHTA
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| Abstract:
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Studies of sexual behavior are particularly suitable for analyses of behavioral and neurobiological
mechanisms of motivation. Epidemiological studies have shown that sexual desire disorders are common,
particularly in women. Psychological treatments for such disorders are time consuming, and the outcome is
uncertain. Therefore, it is very likely that many individual would prefer a reliable pharmacological treatment
without side effects. The systemic development of such treatment requires undoubtedly a good preclinical
model. On the other hand, the valid and reliable model of rodent sexuality would be of great utility to study the
behavioral and neurobiological basis of sexual motivation, due to similarities in basic neural and behavioral
mechanisms controlling sexual desire in humans and rodents. In light of this, the present review focuses on the
various preclinical screening models and methodologies used to evaluate and screen the compounds likely to
affect the various aspects of sexual behavior in female rodents.
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| Keyword:
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Behavioral, Epidemiological, neurobiological, preclinical model
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