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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Microwave assisted synthesis and characterization of certain novel bipyrazole derivatives and their antimicrobial activities

Author: UPLOADED BY-ADMIN, DHANYA B, UJJWAL SAHOO, A.K.SETH, A.K.SEN, S.KUMAR, Y.C.YADAV, T.K.GHELANI, R.CHAWLA
Abstract: The increasing clinical importances of drug resistant bacterial and fungal pathogens have lent an additional urgency in the field of microbiological research and development of new antimicrobial comTpounds. Microwave assisted synthesis is less time consuming and environmental friendly as compared to the existing conventional method of synthesis. Pyrazoles possesses various biological activities such as antibacterial, antifungal, antiviral, antitubercular, antidepressant, anti amoebic, anti-inflammatory, anticonvulsant , analgesic and anticancer activity. In light of these interesting biological activities, it was our interest to synthesize some novel bipyrazole derivatives 4 (a-f). Hydrazone derivatives 1(a-f) have been prepared by reacting INH (Isonicotinic acid hydrazide) with substituted acetophenone. 1(a-f) were treated with POCl3/DMF to afford pyrazole aldehyde derivatives 2(a-f). 2(a-f) were further treated with substituted acetophenone in the presence of C2H5OH/NaOH gave substituted chalcones 3(a-f) and in the presence of INH (Isonicotinic acid hydrazide) gave substituted bipyrazole derivatives 4(a-f). The structure of newly synthesized compounds 4(a-f) have been confirmed by IR, and 1H NMR. All compounds have been screened in vitro for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherchia coli and Pseudomonas aeruginosa, and also for their antifungal activity against Candida albicans and Asperigillus niger. Among the synthesized compounds, 4b, 4c and 4f showed better activity against Candida albicans and compounds, 4a, 4e and 4f showed better activity than rest of compounds against Asperigillus niger when compared with standard drug. Thus, microwave heating technology in drug synthesis should be promoted in order to reducing the cost of basic drugs and chemicals.
Keyword: bipyrazoline, isonicotinic acid hydrazide, antifungal, antibacterial
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