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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A REVIEW: IN SILICO DRUG DESIGN-NOVEL TECHNIQUE IN THE DRUG DISCOVERY PROCESS

Author: MANSIBEN SHAH, NIKI SHAH, MS. SHREYA SHAH, MR. HITESH JAIN, DR. U.M.UPADHYAY
Abstract: Design of a novel drug is one of the biggest challenges faced by the pharmaceutical industry. Increasing costs of drug development and reduced number of new chemical entities have been a growing concern for new drug development in recent years. A number of potential reasons for this outcome have been considered. One of them is a general perception that applied scienceshave not kept space with the advances of basic sciences. Therefore, there is a need for the use of alternative tools to get answers on efficacy and safety faster, with more certainty and at lower.One such alternative tool is the in silico drug design or the Computer Aided Drug Design (CADD). In silico methods can help in identifying drug targets via bioinformatics tools. In silico drug design can play a significant role in all stages of drug development fromthe preclinical discovery stage to late stage clinical development. Its use in drug development help in selecting only a potent lead molecule and may thus prevent the late stage clinical failures and the use of computers accelerate the process of drug design which is a time intensive process, and also reduces the cost of whole process.
Keyword: In Silico Drug Design, Computer Aided Drug Design, Virtual Screening, Highthrough Put Screening.
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0.12
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