IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Preparation and Physicochemical Characterization of Methotrexate PLGA Microparticles

Author: UPLOADED BY-ADMIN, HARSHA V PATEL, BHARAT G PATEL, VISHNU A PATEL
Abstract: The development of injectable microparticles for anticancer drug delivery is a major challenge. The microparticles were prepared by solvent evaporation method. The physico-chemical characteristics (% yield, drug content, t50) were affected by various parameters e.g. types of disperse phase and continuous phase and excipients of disperse phase was studied. The % practical yield and drug content was significantly influenced by continuous phase. In aqueous continuous phase practical yield and drug content was very low which was improved by substitution of oily continuous phase. From in-vitro release profile % was higher in aqueous continuous phase. It showed biphasic release pattern. The initial burst was due to hydrophilic nature of drug and sustenance in release imparted by lipophilic nature of polymer. This modification of drug release was obtained in appropriate combination of drug polymer ratio which was studied preliminarily.
Keyword: Malignancy, Methotrexate (MTX), Microparticles, Solvent diffusion, PLGA
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free