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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design and synthesis of some newer hydroxamic acid derivatives as Histone Deacetylase inhibitors.

Author: JAGANNATH BEHERA, DR. B.N. SINHA
Abstract: Twelve new molecules, containing aromatic linker, have been designed, synthesized and tested for Histone Deacetylase (HDAC) inhibitory activity. Compounds were designed making modification at cap and linker region of standard molecules. The linker selected was 3-amino benzoic acid and cap region consists of substituted aldehydes and ketones. Two molecules among them compounds SBH 3 & SBH 12 showed activity at 2.5µM & 6µM. Other molecules were either less active or having no activity (SBH-4 & 6). The binding mode interaction are explored between active molecule (SBH 3) and binding pocket of receptor (PDB ID 1T69).
Keyword: Histone Deacetylase, linker, binding mode, 3-aminobenzoic aid
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0.12
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