*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *         Journal is Currently Not Indexed in Scopus as on february 2021 list Updated by scopus

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design and synthesis of some newer hydroxamic acid derivatives as Histone Deacetylase inhibitors.

Author: JAGANNATH BEHERA, DR. B.N. SINHA
Abstract: Twelve new molecules, containing aromatic linker, have been designed, synthesized and tested for Histone Deacetylase (HDAC) inhibitory activity. Compounds were designed making modification at cap and linker region of standard molecules. The linker selected was 3-amino benzoic acid and cap region consists of substituted aldehydes and ketones. Two molecules among them compounds SBH 3 & SBH 12 showed activity at 2.5µM & 6µM. Other molecules were either less active or having no activity (SBH-4 & 6). The binding mode interaction are explored between active molecule (SBH 3) and binding pocket of receptor (PDB ID 1T69).
Keyword: Histone Deacetylase, linker, binding mode, 3-aminobenzoic aid
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