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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Estimation of Aspirin and Atorvastatin Calcium in Combine Dosage Form Using Derivative Spectrophotometric Method

Author: UPLOADED BY-ADMIN, PATEL G. F, VEKARIYA N. R., DHOLAKIYA R. B
Abstract: A simple and reproducible spectrophotometric method, requiring no prior separation, has been developed for the estimation of Aspirin and Atorvastatin Calcium in combined dosage form. Second order derivative spectroscopy method was adopted to eliminate spectral interference, using 266.78nm and 237.35nm as zero crossing points for Aspirin and Atorvastatin Calcium respectively. Methanol was used as a solvent. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.
Keyword: Second derivative spectroscopy, Aspirin (ASP), Atorvastatin Calcium (ATO).
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