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Anti-inflammatory and Analgesic Activity of Cicer Arietinum.L. Plant Extracts in Rats
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| Author:
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PERUKA LATHA, A. SRINIVASA RAO, OMKIRAN DHAKATE, SATISH GUNDA, RAMACHANDRA M
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| Abstract:
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Objective: To evaluate the analgesic & anti-inflammatory activity of Cicer arietinum.L. Plant extract on rats.
Materials and methods: Methanol and Aqueous extracts of Cicer arietinum.L. Whole plant except seeds (MECA & AECA respectively) were prepared and studied for analgesic & anti-inflammatory activities using Eddy’s hot plate method and carrageenan induced paw edema in rats respectively. Inflammation was induced by administration of 1% carrageenan solution into the sub plantar region of left hind paw of rat.
Results: In the evaluation of analgesic activity the animals treated with MECA (200mg/kg & 400mg/kg), AECA (200mg/kg & 400mg/kg), and standard pentazocin (10mg/kg) has significantly reduced the hot plate induced jumping & licking responses when compared with control group & high doses of MECA (3.85 ± 0.189 a, 5.75 ± 0.314 a b) & AECA (3.73 ± 0.197 a, 5.53 ± 0.294 a b) with Pentazocine treated rats (4.03 ± 0.221a, 6.35 ± 0.377 a) at 30min & 60 min respectively . In the screening of anti-inflammatory activity the animals treated with MECA (200mg/kg - 0.23 ± 0.004ab & 400mg/kg- 0.2 ± 0.009a), AECA (200mg/kg - 0.24 ± 0.004ab & 400mg/kg - 0.21 ± 0.021a) & standard diclofenac sodium (5mg/kg) has significantly reduced the inflammation when compared with carrageenan induced inflammation in positive control group animals at 90 minutes.
Conclusion: The results of the study concluded that Cicer arietinum. L Plant extracts exhibits an anti-inflammatory and analgesic activity and further studies were suggested to isolate the active principles responsible for the activity.
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| Keyword:
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Analgesic, anti-inflammatory, carrageenan , Cicer arietinum.L, diclofenac sodium, , Pentazocin,
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