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Influence of process parameters on the performance of hydrolyzed polyacrylamide grafted maize starch based microbeads
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| Author:
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ANAND DESHMUKH, C. MALLIKARJUNA SETTY, ARAVIND M. BADIGER
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| Abstract:
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The present investigation demonstrates the effect of processing factors (% drug loading, cross linking agent concentration and curing time) on the overall performance of hydrolyzed polyacrylamide grafted maize starch (HPam-g-MS) based pH responsive microbeads. The graft copolymer was synthesized by microwave assisted grafting and partially hydrolyzed to enhance its functionality and characterized using FTIR, neutralization equivalent, viscosometry and elemental analysis. Eco-friendly ionic gelation method was used to prepare the different batches of pH responsive microbeads and evaluated. Drug entrapment efficiency was found between 69 % and 88 % and size of microbeads were between 1307 µm and 1462 µm . Results of in vitro dissolution study, performed in two different pH conditions (pH1.2 and pH7.4) showed that processing factors had a direct impact on drug release and its transport mechanism, which was shifted from Fickian in acidic to non-Fickian in alkaline media. Further, alkaline pH accelerated both the release of enclosed drug and swelling of microbeads as compared to acidic pH. SEM micrographs provided the view of morphological changes in surface with change in pH of surrounding media. Short term stability study in accelerated conditions ensured the stability of developed formulations. In conclusion, hydrolyzed polyacrylamide grafted starch based microbeads can be suitably tailored by changing the process parameters to meet the desired therapeutic needs and therefore, holds the immense potential for application in site specific oral delivery of various therapeutic agents.
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| Keyword:
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starch microbeads, polyacrylamide grafted, pH responsive, sustained delivery, microbeads, kinetic study
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| DOI:
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