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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Design and Evaluation of Matrix Tablets Containing a Natural Polysaccharide as a Carrier to Optimize Active Drug's (Nsaid) Absorption Profile for Bedtime Administration (Chronotherapeutic Delivery)

Author: UPLOADED BY-ADMIN, PRATIK SHAH, PRAGNA SHELAT
Abstract: The purpose of this research was to develop and evaluate a matrix system for Chronotherapeutic delivery of NSAID (Non-steroidal anti-inflammatory drug) containing Natural Polysaccharide in Rheumatoid Arthritis. The natural polysaccharide, Guar gum, was used as a carrier for drug delivery along with three different polymeric binders to optimize the proper formulation for Chronotherapeutic drug delivery. Materials and methods: Different batches of matrix tablet of Diclofenac Sodium- Guar gum were prepared using wet granulation method and evaluated by different in vitro tests and release profiles. Three polymeric binders were used in different proportion to produce nine different batches. Result and discussion: The release profile of Diclofenac Sodium from the matrix tablets is dependent upon the gelling property of Guar gum and degradation of Guar gum by colonic bacteria. In Stomach, the release rate was much slower; however, the drug was released quickly in the lower part of GIT after 4 hours. The prepared matrix tablets showed good mechanical properties (hardness and friability). Hydroxy Propyl Methyl Cellulose and Poly Vinyl Pyrolidine K30 based tablet formulations showed high release-retarding efficiency and release higher amount of drug in lower part of GIT. Mathematical modeling suggests the First order kinetics for the matrix tablets and Non-Fickian Super Case II transport mechanism. Stability of the drug release profiles when stored for 3 months in ambient temperature, 40°C, and 50°?C suggesting that Guar gum based matrix tablets are good candidates for preparing modified release diclofenac tablet formulations for lower GI tract specific drug delivery. Conclusion: It is concluded from the present investigation that Guar gum containing matrix tablets are promising controlled release systems for colon-targeted delivery of Diclofenac Sodium. These matrix tablets are able to achieve site-specific drug delivery at colon following oral administration and thus satisfying chronotherapeutic need for arthritic pain management by delivering Diclofenac Sodium.
Keyword: Chronotherapeutic drug delivery system (CDDS); Colon Targeting; Guar gum; Diclofenacsodium; Matrix tablet.
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0.12
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