|
Qualitative phytochemical analysis and antioxidant activity of Aporosa octandra (Buch.-Ham. ex D. Don) extracts.
|
|
| Author:
|
VABEIRYUREILAI MARA, K.LALRINZUALI, G.ROSANGKIMA, GANESH CHANDRA JAGETIA
|
| Abstract:
|
Aporosa octandra is a shrub or tree growing upto 15metres tall, mostly found in Asia. The scientific report relating to its medicinal values is limited though there are several reports on traditional uses in Asia including NE States of India. This plant is used to treat many ailments in Mizoram. Therefore, considering the importance of antioxidants in scavenging activity agents, the present study was undertaken to qualify the phytochemicals, phenolic contents, flavonoid content and its antioxidant activity in cell free systems in vitro. The phytochemical analysis revealed the presence of tannins, saponins, flavonoids, tarpenoids and cardiac glycosides but phlobatannins was found to be absent. The phenolic content of A. octandra in both chloroform and ethanol extract was measured by gallic acid equivalent and found to be higher in ethanolic extract 1010.67±58 (EtEx) than chloroform extract 282.67±26(ChEx) at the concentration of 500µg/ml. However, flavonoid content was found to be higher in chloroform extract 668.8±3.94 (ChEx) than ethanolic extract 635.61±4 (EtEx) at the concentration of 500µg/ml. In the present study, DPPH, hydroxyl radical and superoxide anion scavenging properties of chloroform and ethanolic extract of A. octandra was measured at different concentrations (1-2500µg/ml) and found that the radical scavenging activity of both chloroform and ethanol extracts were dose-dependently increases up to 500 µg/ml followed by a decline thereafter. Nitric oxide free radical scavenging activity was also found dose-dependently increases up to 200µg/ml and 100µg/ml respectively. Therefore, it can be concluded that chloroform and ethanol extract of A. octandra with potent antioxidant properties may be useful agents in the prevention and treatment of some types of human diseases particularly in cancer.
|
| Keyword:
|
Aporosa octandra, free radical, flavonoids, phenols
|
| EOI:
|
-
|
| DOI:
|
-
|
| Download:
|
Request For Article
|
|
|