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MICROSPONGES: A REVOLUTIONARY PATH BREAKING MODFIED DRUG DELIVERY OF TOPICAL DRUGS
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| Author:
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CHAINESH SHAH, DHIREN SHAH
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| Abstract:
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The drug delivery technology landscape has become highly competitive and rapidly evolving. Additionally more developments in delivery systems are being incorporated to optimize the efficacy and cost-effectiveness of the therapy. The purpose of writing this review to pile up the modern information’s, current technologies and recent literatures and other contributing factors used to acquire controlled release of active drug and minimize the drawbacks of topical drug delivery systems like local cutaneous reactions i.e. unpleasant odour, greasiness and skin irritations and fail to reach the systemic circulation in sufficient amount which could be overcome by using a unique, versatile and novel approach- Microsponge drug delivery system. Microsponges are stable over range of pH 1 to 11; stable at the temperature up to 1300C; compatible with most vehicles and ingredients. Microsponge can be effectively incorporated into topical drug delivery system such as creams, lotions, gels, ointments, and powder for retention of dosage form on skin, and also use for oral delivery of drugs using bioerodible polymers, especially for colon specific delivery and controlled release drug delivery system consequently providing site specific drug delivery system, prolonging dosage intervals and share a broad package of benefits thus improving patient compliance. The present review introduces Microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of MDS.
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| Keyword:
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Microsponges, microporous beads, Topical drug delivery, Solvent Diffusion Method, Quasi-Emulsion.
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| EOI:
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| DOI:
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| Download:
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