*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *         Journal is Currently Not Indexed in Scopus as on february 2021 list Updated by scopus

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Potent Antibacterial Activity of Quinoxaline 1, 2, 3-Triazole Derivatives

Author: SACHIN SHIRAME, RAGHUNATH B.BHOSALE1, SHARVAN Y.JADHAV
Abstract: ABSTRACT Synthesis of 1, 2, 3-triazole quinoxaline derivatives (4a-l) using 1, 3-dipolar cycloaddition (click chemistry) reaction of 6-azido -5-bromoquinoxaline (2a) with various substituted alkynes (3a-l) in the presence of Cu (I) catalyst has been achieved in very high yields. Some synthesized compounds were characterized by IR, 1H NMR, C13 NMR and Mass spectroscopy. All these compounds were evaluated for their in vitro antimicrobial activities. Among these compounds 4a, 4d, 4e, 4h and 4i have shown good antibacterial activity against different human pathogens.
Keyword: Key words: 1, 2, 3-triazole, quinoxaline, Antibacterial, Antifungal activity.
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