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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Colon Targeted Oral Delivery of Ornidazole Using Combination of pH and Time Dependent Drug Delivery System.

Author: UPLOADED BY-ADMIN, J.M.PATEL, M.R.BRAHMBHATT, V.B.PATEL, S.V.MULEY, P.G.YEOLE
Abstract: The objective of this study was to evaluate the combination of pH-dependent and time-dependent polymers by a statistical full factorial design. Eudragit S100 was used as pH-dependent polymers and Eudragit RS100 and Eudragit RL 100 were used as a time-dependent polymer. Ornidazole was taken as a model drug. Dissolution studies of tablets in the media with different pH (1.2, 7.4 and 6.8) showed that drug release in colon could be controlled by addition of Eudragit RS and Eudragit RL100. The various batches were prepared by using 32 full Factorial design in which X1 was the ratio of Eudragit RS 100 to the RL 100 (25%, 50%, 75%) and X2 was the coating level of Eudragit S100 ( 0%, 5%, 10%). Two response variables were amount of drug release up to 5 hr. and amount of drug release up to 12 hr. An optimized formulation was found to be the one containing 5% coating of Eudragit RS:Eudragit RL (1:1) and 10% coating level of Eudragit S100.The experimental values of response variables highly agreed with predicted values. From results obtained in the present study, it was concluded that an optimized formulation successfully deliver the maximum amount of drug in intact form to the colon.
Keyword: Colon targeted drug delivery system, Ornidazole, pH-dependent, pH-independent, Eudragit
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