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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Colloidal Drug Carriers for an Anticancer Drug Paclitaxel

Author: UPLOADED BY-ADMIN, SIDHARTH M. PATIL, RAJENDRA C. DOIJAD
Abstract: Solid Lipid Nanoparticles (SLNs) are colloidal carriers which shown a promising utility in the delivery of various drugs in controlled manner as well as it is having high encapsulation efficiency. Paclitaxel is a potent chemotherapeutic agent used in the treatment of various malignancies. This chemotherapeutic agent is associated with limited bioavailability due to side effects associated with solubilizer used in its commercial formulation and its tendency to precipitate severe side effects like anaphylactic reaction. In this study paclitaxel solid lipid nanoparticles were prepared and were subjected to various evaluation studies. Microemulsification method was used to prepare 3 batches of pacli-sln with different lipid concentration keeping drug concentration unchanged. Particle size was ranged between 175-393 nm. Drug entrapment was found to be 38.90, 51.40 and 62.20 with practical yield of 45.66, 48.44 and 59.40 percent for F1, F2 and F3 batches respectively. SEM showed spherical shape and smooth surface morphology. Release studies were carried using phosphate buffer pH 7.4, using dialysis bag diffusion technique. At the end of 48 hrs in vitro drug release found to be 66.567 to 84.278 %. Release was found to follow Higuchi’s classical diffusion model. Study concluded that paclitaxel loaded SLNs were stable and released the drug for extended periode, further studies should be performed to assess the biodistribution and targetability to tumors.
Keyword: Anti- cancer drug, SLN, Paclitaxel, DPPC.
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