*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *         Journal is Currently Not Indexed in Scopus as on february 2021 list Updated by scopus

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Development and validation of first order derivative UV spectrophotometric method for simultaneous estimation of Fluorometholone acetate and Ketorolac tromethamine in ophthalmic dosage form

Author: JANKI SHAH, MAHESHWARI D.G.
Abstract: A simple, accurate and precise First order derivative spectrophotometric method developed for the simultaneous estimation of Fluorometholone acetate (FLU) and Ketorolac tromethamine (KTC) in ophthalmic dosage form. The first derivative values were measured at 296nm for KTC and 226nm for FLU. The linearity range for zero order was carried out by using the concentration range 10-70µg/ml for both the drug. The correlation coefficient of FLU and KTC for zero order was found to be 0.999 and 0.998 respectively. At zero crossing point (ZCP) of KTC (296nm) FLU showed a measurable derivative absorbance where as at zero crossing point (ZCP) of FLU (226nm) KTC showed an appreciable derivative absorbance value. Precision study showed that % RSD was within range of acceptable limits (<2%). The % recovery for FLU and KTC was found to be within range of 98-102% and 98-101%respectively. The percentage assay was found to be 98.24% and 99.18% for FLU and KTC. The result of analysis has been validated as per ICH Q2 (R1) guideline.
Keyword: Fluorometholone acetate (FLU), Ketorolac tromethamine (KTC), UV Spectrophotometry, First order derivative Spectrophotometry.
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free