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Evaluation of Zingiber officinale Effects on Rifampicin Pharmacokinetic Parameters Using Animal Model
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| Author:
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EBERE EMILIA, AYOGU, KOSISOCHI CHINWENDU AMORHA, OLUCHUKWU OKPALAOKA, MATHEW JEGBEFUME OKONTA
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| Abstract:
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The effect of ginger extract on the pharmacokinetic parameters of rifampicin and its penetration into the lung was
investigated. Fifteen albino rats were divided into three groups. Group A received rifampicin 10 mg/kg alone orally;
Groups B and C received 5 and 10 mg/kg of ginger extract, respectively, for 10 days and on day 11, they received 10
mg/kg rifampicin as in group A. Blood samples were collected at different time intervals and assayed. Treatment with 5
mg/kg ginger significantly (p=0.03) increased Tmax by 93 % and decreased t1/2 by 72% (p=0.04), with a non-significant
decrease in Cmax, by 18 %, while treatment with 10 mg/kg ginger resulted in a significant decrease in t1/2 (p=0.02) 59 %
with a non-significant (p=0.67) increase in Tmax by 7 %, decrease in Cmax, and AUC, by 8 and 5 % respectively. Concurrent
administration of ginger and rifampicin resulted in significant decrease (p=0.04) in the concentration of rifampicin that
penetrated the lung from 14.63±4.06 in rifampicin alone to 9.99±4.06 and 9.14±0.97 for 5 and 10 mg/kg ginger. This
study reported that ginger caused significant change in the pharmacokinetic parameters of rifampicin when taken
concurrently and also decreased concentration of rifampicin in the lungs.
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| Keyword:
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Ginger, Rifampicin, Pharmacokinetics, Lung penetration
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| EOI:
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http://eoi.citefactor.org/10.11209/ijpr.10.03.011
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.03.039
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| Download:
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