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Estimation of Apolipoprotein A, Apo B, Apo E and
SomeBiochemical Markers in Type 2 Diabetic Patients
in Iraq
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| Author:
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HUDA JABER, MOHAMMED ABDULJALIL, HAYDER ALKURAISHY
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| Abstract:
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Insulin resistance association with obesity and diabetes is described by rise the plasma TG-rich lipoprotein levels.
Apolipoprotein (apo) plays a major role in the lipid metabolism and lipoproteins transport.The study was designed to
investigate the levels of several type of Apolipoprotein ( Apo A, Apo B and Apo E) and other biochemical markers in
type 2 diabetic patients and their relation with development of diabetic complications.Total of (40) patients of T2DM
were selected in the study. For comparison, thirty healthy subject were enrolled in the study. Serum Apo A, Apo B and
Apo E was measured. Other biochemical markers also determined which include serum C-peptide, glycosylated
hemoglobin, FBS and lipid profile.Type 2 diabetic patients had significantly higher levels of Apo A than matched controls
(270±72 vs.160±26 mg/dl, <0.0001), as well as, serum Apo E levels significantly increase in diabetic patients when
compare to control group, while serum Apo B considerable higher in patients compared to control but the difference
was not statistically significant. Plasma triglycerides were positively and independently correlated with Apo A levels. In
conclusion, Apo A and Apo E can be used to follow diabetes and its complications
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| Keyword:
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Type 2 diabetes, Apolipoprotein A, Apo B, Apo E , C-peptide
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| EOI:
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http://eoi.citefactor.org/10.11209/ijpr.10.03.004
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| DOI:
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-
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| Download:
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