*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Study for The preventive Effects of AjwaDates Alcoholic Extract on TheHepatic Tissue Functions and lipid ProfileRegression Induced byOchratoxin A in Male Albino Rats

Author: DR.ALAAA ALI, DR.SAHER MAHMOOD JWAD
Abstract: The present study designed to investigate the possible efficacy of alcoholic extract of Ajwa fruit to prevent the hepatotoxicity and retrogression of the lipid profile that may be induced by OchratoxinA .This study was carried out in the animal house of Biology department – Faculty of Education for Girls ,forty male rats of strain ( Sprague – Daw ley ) were equally divided into four groups , the control ( first group ) was orally treated with 0.9% of normal saline solution , second group was also orally administrated with Ochratoxin A ( 289 µg / kg ) , the third group was orally received alcoholic extract of Ajwa dates ( 1 mg / kg ) + 289 µg / kg of Ochratoxin A respectively , while the fourth group was subjected to 1 mg / kg of Ajwa dates alcoholic extract + Ochratoxin A at the concentration of 289 µg / kg orally . The treatment of the four groups was once daily for the period of five days weekly. The statistical analysis for the results of present study has been showed a noticeable rise ( P< 0.05 ) in the levels of total cholesterol , triglycerides , low density lipoproteins ( LDL ) very density lipoproteins ( VLDL ) , total bilirubin , whereas a significant reduction ( P< 0.05 ) was revealed in the high density lipoprotein (HDL ) and glutathione levels in the experimental group of laboratory animals that submitted to Ochratoxin A in compared with the other groups of study .With regard to the histological examination for the liver sections of rats that treated with this type of the fungal toxin, several detrimental changes were diagnosed when compared with the othergroups. In the conclusion,Ajwa dates alcoholic extract was alleviated the deteriorative impacts of Ochratoxin A on the hepatic tissues and the lipid profile due to its effective chemical ingredients and potentialities.
Keyword: OchratoxinA , Ajwa ,glutathione.
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03
DOI: https://doi.org/10.31838/ijpr/2018.10.03.027
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free