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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Impact Factor: 1.55

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FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM (5A / 6A) IN REGION -1171 OF THE PROMOTER OF MATRIX METALLOPROTEINASE 3 GENE IN PATIENTS WITH OVARIAN CANCER IN FARS PROVINCE

Author: YAGHOOB TAHERI1*, KALAVANI MARYAM, HOUSHANG JAMALI
Abstract: Ovarian cancer is the fourth leading cause of death in women. One of the main causes of mortality in these patients is the late referral of women with ovarian cancer despite proper treatment. Matrix metalloproteinases (MMPs) are a large family of protease enzymes. The polymorphisms associated with this gene, as well as MMP3, can be effective in changing the tissues in a variety of physiological and pathological conditions, such as tumorigenicity, cancer spread and metastasis. The present study evaluates the effect of polymorphism of single-nucleotide of MMP3, -1171 5A / 6A, matrix metalloproteinase gene promoter on ovarian cancer. In this study, 100 samples in the group of patients and 100 samples in the control group, which were referred to one of the hospitals in Fars province in the year 96-95, received venous blood sampling. After sampling and DNA extraction, the desired polymorphism was multiplied by PCR method according to ordered primers and eventually cut by TthI111 restriction enzyme. After determination of genotype in control and patients, frequency of 5A / 5A, 6A / 6A and 5A / 6A genotypes was determined in two groups and their distribution was statistically compared.The results showed that the highest frequency of MMP3 gene polymorphisms in control group was related to genotype 5a / 6a (normal homozygote) (81%). The lowest frequency of MMP3 gene polymorphism was in the control group of 5A / 6A (homozygous patient) (5%). The highest frequency of MMP3 gene polymorphisms and the lowest frequency of polymorphism was related to 5A / 6A (homozygous patient) (21%). The frequency of heterozygote (5a / 6A) in this group was 33% as well. Mutant gene of MMP3-1171 in the form of homozygous 5A / 6A and heterozygous 5A / 6A contribute to ovarian cancer in Fars province and the spread of ovarian cancer in homozygous carriers and heterozygote 5a / 6A alleles has been more pronounced.
Keyword: Single nucleotide polymorphism, region -1171, Matrix metalloproteinase 3, ovarian cancer
DOI: https://doi.org/10.31838/ijpr/2018.10.03.007
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477