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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Novel Alternative to Ocular Drug Delivery System: Hydrogel

Author: UPLOADED BY-ADMIN, DIVYESH SHASTRI, L. D. PATEL
Abstract: Sustained and Prolonged drug delivery approaches are very common in today’s Pharmaceutical formulation design and research work is still going on in achieving better drug product. Ophthalmic use of viscosity-enhancing agents, penetration enhancers, cyclodextrins, prodrug approaches, ocular inserts and the ready existing drug carrier systems along with their application to ophthalmic drug delivery are very common to improve ocular bioavailability. Amongst these hydrogel (insitu gel forming) systems are of very important. They help to increase in precorneal residence time of drug to a sufficient extent that an ocularly delivered drug can exhibit its maximum biological action. The concept of this innovative ophthalmic delivery approach is to decrease the systemic side effects and to create a more pronounced effect with lower doses of the drug. Many polymers are very useful with majority of hydrogels, which undergo reversible sol-gel phase transitions in the ocular cul-de-sac to form viscoelastic gels due to phase changes of polymers in response to the physiological environment (temperature, pH and presence of ions in organism fluids. These insitu forming gels can be applied as solution and exhibit pseudo plastic behavior to minimize interference with blinking, increase precorneal residence of the delivery system and enhanced ocular bioavailability. Now a days insitu gels have been used as vehicles for the delivery of drugs for both local treatment and systemic effects. Different administration routes other than ocular have been explored, including for example, cutaneous and subcutaneous delivery, dental, buccal delivery and delivery to the esophagus, stomach, colon, rectum and vagina.
Keyword: Ocular drug delivery, Environment sensitive, Preformed, Insitu, Hydrogel.
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0.12
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