IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Development and Validation of sensitive HPTLC method for quantitative analysis of fluvastatin sodium in bulk and pharmaceutical dosage form

Author: ASHOK AKABARI, UMANG SHAH, SAGAR SOLANKI, MANDEV B PATEL , BHANUBHAI N SUHAGIA
Abstract: A simple, sensitive and robust high performance thin layer chromatography method for determination of fluvastatin sodium in capsules dosage form has been developed and validated. Fluvastatin sodium from the formulations was separated and identified on aluminium backed silica gel 60 F254 HPTLC plates as a stationary phase using methanol–ethyl acetate-toluene-glacial acetic acid (3:5:1.8:0.2, v/v/v/v) as mobile phase. Densitometry scanning was performed in absorbance mode at 235 nm. Well-resolved bands were obtained of fluvastatin sodium in bulk and capsules dosage form. The plates were developed to a distance of 8 cm. Percentage relative standard deviation of intra-day and inter day precision, were found 0.59 -0.95% and 0.9 -1.73 % respectively. Statistical analysis proved that the method was precise, accurate and robust. The limits of detection and quantification were 26.74 and 81.05ng/band. The method was fully validated for linearity, specificity, accuracy, precision, repeatability, and robustness to prove its suitability for determination of fluvastatin sodium in bulk and capsule dosage form in accordance with ICH guidelines.
Keyword: Fluvastatin Sodium, HPTLC, Anti-Hyperlipidemic agent, Densitometric analysis, Validation
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free