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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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“s-Triazine based dendrimer mediated solubilisation of Ketoprofen, Ibuprofen and Diflunisal”

Author: PRAVINKUMAR PATEL, HEMA N. PATEL, RINKESH M. PATEL, DHAVAL G. GAJJAR
Abstract: s-triazine based dendrimer was synthesized up to generation 3 by divergent method. N,N'-(methylenebis(4,1-phenylene))bis(4,6-dichloro-1,3,5-triazin-2-amine) was synthesized as core for dendrimer synthesis in first step. Dendrimer was then grown to generation 3 by using diethanolamine and triazine trichloride as branching units. Synthesized dendrimers were characterized by 1H-NMR, 13C-NMR, ESI-Mass spectrometry and elemental analysis. Dendrimer generations G1, G2, G3 were used to enhance aqueous solubility of NSAIDS such as Ketoprofen, Ibuprofen and Diflunisal. Effect of factors such as pH, generation and concentration of dendrimer of solubility of NSAIDs were studied. It was found that with increase in pH, generation number and concentration of dendrimer solubility of NSAIDS increased. The order of solubility of NSAIDs was found to be Ketoprofen> Ibuprofen> Diflunisal.
Keyword: Triazine trichloride, Dendrimer, Solubility enhancers, Nonsteroidal Anti-inflammatory Agents.
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