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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Estimation of Imatinib in pure and pharmaceutical forms using triphenyl methane dyes

Author: T. VEERAIAH*, CH. VENKATA RAMANA REDDY
Abstract: Simple and sensitive extractive spectrophotometric methods for the determination of Imatinib in pure form and in pharmaceutical formulations using triphenyl methane dyes have been developed. The developed methods involved formation of coloured chloroform extractable ion-pair complexes of Imatinib with triphenyl methane dyes viz., bromothymol blue, bromophenol blue, bromocresol green and bromocresol purple in acidic medium. The extracted complexes formed with the above dyes showed absorbance maxima at 415, 416, 412 and 407 nm respectively, The stoichiometry of the ion-pair complexes of Imatinib with dyes is found to be 1:1 in each case and Beer’s law is obeyed in the concentration range 2.5- 25µg/ml of drug with dyes. The effect of concentration of dye, pH, and interference of excipients has been studied for optimization. The limits of detection and quantification have been determined for all the four methods. These methods have been validated as per the guidelines of ICH. The results of analysis were validated statistically through recovery studies.
Keyword: Spectrophotometry, Imatinib, Triphenyl methane dyes, Resimat tablet, Ion-pair complex, Validation
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