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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Upregulation of BRCA1, ERBB2 and TP53 marker genes expression in breast cancer patients.

Author: ABDULRAZZAQ ZGHAIR, ROHIT SHARMA, MOHAMMED ALFAHAM, ANIL K SHARMA*
Abstract: Breast cancer is considered as the most common malignant disease, especially among Indian women that accounts for the highest rate of morbidity and mortality. BRCA-1, ERBB-2 and TP-53 are amongst the high risk genes of breast cancer. Mutations in these genes account for a considerably higher incidence of breast cancer initiation and development. In breast cancer , BRCA-1 gene is considered as the most predisposing genetic factor. Similarly, ERBB-2 and TP-53 are also observed as the main prognostic markers in the treatment of breast cancer. This study was designed to know the gene expression profile of the molecular markers namely, breast cancer 1 (BRCA-1), human epidermal growth factor receptor 2 (ERBB-2) and tumor suppressor gene (TP-53) expression by the real time polymerase chain reaction (PCR). The mutational analysis in particular exons of BRCA-1 (exon 11),ERBB-2 (exon 16) and TP-53 (exon 5) was further investigated by Sanger-Sequencing in the above breast cancer patients of north Indian origin. The TP-53 mRNA levels have been significantly expressed in cancer tissues as compared to the normal ones. Similar trends were observed with BRCA-1 and ERBB-2 mRNA expression as well. We conclude from this work that the differential gene expressions of BRCA-1, ERBB-2 and TP-53 at the mRNA level may act as a diagnostic marker with a significant prognostic value in Breast cancer patients.
Keyword: Breast cancer , BRCA-1, ERBB-2 , TP-53, gene expression, prognosis
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