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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of in vivo antioxidant activity of methanol extract of Buddleja asiatica

Author: RAJA. S, RAMYA. I
Abstract: Previously, we reported the in vitro antioxidant activity of methanol extract of whole plant of Buddleja asiatica. The aim of present study was to assess the effects of oral administration of Buddleja asiatica to 18 healthy rats with particular attention to their in vivo antioxidant property. The rats were administered with methanol extract of Buddleja asiatica at two different doses (250mg/kg, 500mg/kg) for a period of 21 days to estimate the oxidative stress parameters including ferric reducing ability of plasma (FRAP), lipid peroxidation, reduced glutathione (GSH) and evaluated for antioxidant enzyme levels of catalase and superoxide dismutase in serum and tissue homogenates. FRAP analysis showed that the high dose (500mg/kg) of methanol extract possessed better reducing power in comparison to low dose group and control group. Pretreatment with methanol extract of Buddleja asiatica illustrated a significant (p<0.05) increase in serum catalase and superoxide dismutase activity when compared with other groups. The extract at the dose level of 500 mg/kg significantly restored the levels of catalase, superoxide dismutase and reduced glutathione in selected tissue homogenates. In addition, the tested doses of methanol extract of Buddleja asiatica (250mg/kg and 500mg/kg) possessed antioxidant activity by effectively preventing lipid peroxidation in serum and tissues. The extent of decrease in lipid peroxidation in serum and tissue homogenates, suggested a role for the extract in reduction of oxidative stress. The results indicated that methanol extract of Buddleja asiatica could serve as free radical scavenger or primary antioxidants.
Keyword: Buddleja asiatica, Oxidative stress, Antioxidant enzymes, Superoxide dismutase, Lipid peroxidation
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