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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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EFFECT OF PARTICLE SIZE ON DISSOLUTION PROFILE OF CIPROFLOXACIN HYDROCHLORIDE FROM FLOATING MATRIX TABLET

Author: DIPANJAN GHOSH, DEBABRATA GHOSH DASTIDAR, RITAM BAIRAGI, SWATI ABAT, ARINDAM CHATTERJEE
Abstract: Ciprofloxacin hydrochloride is a good candidate drug for gastro retentive drug delivery system (GRDDS). Floating tablet of ciprofloxacin hydrochloride was prepared with wet granulation method using HPMC as matrix material and PVP-K30 as binder. The objective of this study was to find out the effect of granule size on the floating behavior and drug release profile. Tablets were prepared with granules of different particle size (over size to mesh no. 22, 22/44, 44/60, 60/85, 85/120, and under size to mesh no. 120). It was found that tablets prepared with finer granules float quickly and remained float for prolonged period of time. The erosion-controlled, zero order drug release mechanism was independent of particle size of granules. But with decrease of granule size, dissolution efficiency was significantly increased. Tablets prepared from granules of mesh no. 85/120 and granules that was undersize of mesh no. 120, were similar with respect to drug dissolution profile, though the later released maximum percentage of drug (98±2%) and had maximum dissolution efficiency of 47±2% in 8 h.
Keyword: Floating tablet, Wet granulation, DDSolver, similarity factor, difference factor, Ciprofloxacin hydrochloride Abbreviation :HPMC=Hydroxy-propyl methyl cellulose, PVP= Polyvinyl Pyrrolidone, GIT=Gastro-intestinal Tract, GRDDS= Gastro Retentive Drug Delivery System, FDDS= Floating Drug Delivery System
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