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Analgesic and anti-inflammatory activity of leaves of Morinda tinctoria Roxb.
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| Author:
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UPLOADED BY-ADMIN, SRIKANTH JEYABALAN, MURALIDHARAN PALAYAN
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| Abstract:
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The aim of the present study was to evaluate the analgesic and anti-inflammatory activity
of the methanolic extract of leaves of Morinda tinctoria. The preliminary phytochemical
screening of the leaves revealed the presence of saponins, terpenoids, tannins, flavonoids,
glycosides and sugars. The central analgesic activity of the extract was evaluated using eddy’s
hot plate method and formalin test whereas peripheral analgesic activity using acetic acid
induced writhing test. The extract was studied for anti-inflammatory activity in carrageenan-
induced hind paw edema in rats and the paw volume was measured plethysmometrically.
The study was carried out using dose (200 and 400 mg/kg, p.o.) of the extract. Pentazocin
(10mg/kg, i.p.) is the standard drug for the centrally acting analgesic activity whereas indomethacin
(10mg/kg, i.p.) is the standard for peripheral acting analgesics and anti inflammatory
activity. The statistical analysis was carried out using one way ANOVA followed by Dunnet’s
test. P value less than 0.5 were considered significant. The methanolic extract of Morinda
tinctoria significantly (p<0.05) reduced carrageenan-induced paw edema in rats and analgesic
activity evidenced by increase in the reaction time by eddy’s hot plate method. It also
significantly inhibited the neurogenic and inflammatory pain in formalin test as well as the
writhing reaction induced by acetic acid. The methanolic extract of Morinda tinctoria showed
significant anti-inflammatory and analgesic effect comparative to the standard drugs. The
pharmacological screening of the extract showed significant antinociceptive activity with anti-
inflammatory profile.
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| Keyword:
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Morinda tinctoria, carrageenan, inflammation, paw edema.
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| EOI:
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| DOI:
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