IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Bioanalytical method development, validation and its application in Pharmacokinetic studies of Verapamil in the presence of Piperine in rats

Author: PRATIBHA AUTI, ASHWINI CHOUDHARY, SATISHGABHE*, KAKASAHEBMAHADIK
Abstract: During our continuingresearch of enhancing bioavailability of drugs by using piperine a known bioenhancer, a suitable bioanalytical method was needed. Here we report the development of a simple RP-HPLC bioanalytical method for determination of verapamil in the presence of piperine. It was carried out on RP C18 column, usingacetonitrile: ammonium acetate buffer (60:40)(pH 5.6 adjusted with acetic acid)as the mobile phase. UV detection was at 288 nm. The calibration plot was linear over the range studied (1-16 ug/ml) with correlation coefficient of 0.998. Limit of detection and limit of quantitation were 0.32 ?g/mL and 0.96?g/mL, respectively. Good overall recovery (98-100%) was obtained. The method is simple, sensitive and reproducible.The developed method was validated as per USFDA guidelines (15) and used in the estimation of verapamil alone and in combination with piperine on oral administration in wistar rats. It was observed that the Cmax and AUC of verapamil increased by 154% and135% respectively when it is given in combination with piperine than verapamil alone.
Keyword: Verapamil, Piperine, Pharmacokinetics, Bioavailability, HPLC, AUC.
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News & Events

CiteScore 2016 -  0.09

SJR 2016 - 0.111

SNIP 2016 - 0.055

Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)