IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Preparation, characterization and cytotoxic effects of nanoliposomes containing umbelliprenin

Author: BIZHAN MALAEKEH-NIKOUEI, ARMAGHAN RAMEZANIA, MEHRDAD IRANSHAHI , MOHAMMAD YAHYA HANAFI-BOJD
Abstract: Drug discovery from plant sources has drawn much attention these years. Natural products are a good source for finding new bioactive compounds. Umbelliprenin (UMB), derivated from Ferula species, has been used and investigated for its pharmacological activities. This natural compound shows various biological effects and one of the most important ones is cytotoxicity and cytostatic activity against tumoral cells. In the present study, to overcome the problem of insufficient water solubility of UMB, after synthesis of this compound with a chemical interaction between 7-hydroxycoumarin and trans-trans-farnesyl bromide, liposomes were selected as a carrier of UMB. The physical characteristics, stability and incorporation of UMB were determined. Then the cytotoxic activity of liposomal UMB against human tumoral cell line A375 was compared to the free form in DMSO. Mean size of liposomes was around 150 nm and they were stable during storage at 4 °C up to two months. The cytotoxicity results indicated that the liposomal UMB had better cytotoxic effects on melanoma cell line compared to the solution in DMSO. This effect was time- and concentration-dependent. Therefore, liposomal carriers showed the characteristics of a perfect system for delivery of UMB and in the future, it may be used in tumor chemotherapy.
Keyword: Cytotoxicity, Liposomes, Umbelliprenin
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free