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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Stability Indicating Method Development And Validation For The Simultaneous Estimation Of Ritonavir, Dasabuvir, Paritaprevir And Ombitasvir In Bulk And Pharmacuetical Dosage Forms By RP-UHPLC

Author: KOTHAPALLI KIRAN, K. KRANTHI KIRAN, DR. A. SRINIVASA RAO, PROF. D. GOWRI SANKAR
Abstract: A Specific, Precise, Accurate, Rugged and Robust stability indicating RP-UHPLC method has been developed and validated for the estimation of Ritonavir, Dasabuvir, Paritaprevir and Ombitasvir in bulk and pharmaceutical dosage form (Tablets) was carried out by Waters UHPLC with HSS-C18 (2.1x100mm, 1.8µm) column as stationary phase by using mobile phase consisting of Buffer: Acetonitrile: Methanol (50:30:20) at a flow rate of 0.5mL/min and detection was carried out at 275nm. The Retention times of Ritonavir, Dasabuvir, Paritaprevir and Ombitasvir 1.151min, 1.854min, 2.522min and 3.454min respectively, The method produced linear response of 25-75µg/mL for Ritonavir, 125-375µg/mL for Dasabuvir, 37.5-112.5µg/mL for Paritaprevir and 6.25-18.75µg/mL for Ombitasvir with >0.999 correlation coefficient. The % Recoveries for Ritonavir, Dasabuvir, Paritaprevir and Ombitasvir were obtained in between 98.0 to 102.0. Main Peak “purity threshold” was obtained greater than peak purity angle in all force degraded samples
Keyword: Ritonavir, Dasabuvir, Paritaprevir and Ombitasvir Waters UHPLC, Acquity HSS C18 and ICH.
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