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Effect of Solvent and Non- Solvent Composition on Physical Characters of Mefloquine Hydrochloride Microsphers
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| Author:
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UPLOADED BY-ADMIN, V.A.PATEL, R.S.R. MURTHY, H.V.PATEL, KUNDAWALA AJ
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| Abstract:
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Mefloquine hydrochloride (MQH) is considered relatively safe effective antimalarial recommended
for prophylaxis and chemotherapy of chloroquine resistant and multidrug resistant
falciparum malaria. Malaria kills nearly one million people worldwide mostly in developing
countries. In present study an attempt was made to produce ethyl cellulose microspheres of
MQH by solvent evaporation method, to see effect of solvent composition on in vitro characterization
of microspheres. The prepared Microspheres were investigated for % drug entrapment,
particle size and in vitro drug release profile. Particle size ranging from 6.82 ± 0.62µm
to 55.58 ± 1.1 µm were obtained with respect to different solvent and non solvent composition
as dispersed and continuous phase. From in vitro drug release studies it was observed
that the values for t50 and t70 were in range of 5-11 day and 6-15 days respectively.
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| Keyword:
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Microspheres, Mefloquine Hydrochloride, Solvent evaporation, Malaria
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| EOI:
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| DOI:
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